Atp1b1 | ATPase, Na+/K+ transporting, beta 1 polypeptide

GeneMGI:88108Synonyms: Atpb, Atpb-1, +1 more

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Integument Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Mortality/aging Craniofacial

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased startle reflex	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	heterozygote	Early adult	1.89x10^-8
preweaning lethality, complete penetrance	3 supporting datasets	Atp1b1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
shortened QRS complex duration	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	heterozygote	Early adult	2.01x10^-5
enlarged testis	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	heterozygote	Early adult	9.63x10^-7
abnormal neural tube morphology	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal pharyngeal arch morphology	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal vitelline vasculature morphology	1 supporting dataset	Atp1b1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp1b1.

Associated images

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Histopathology

There is no histopathology data found for Atp1b1.

IMPC related publications

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External links

No external links available for Atp1b1.

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*Atp1b1^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Atp1b1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Atp1b1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Atp1b1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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