Atp1b1 | ATPase, Na+/K+ transporting, beta 1 polypeptide
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Reproductive system Endocrine/exocrine gland Integument Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Mortality/aging Craniofacial
11 No significant impact
2 Not tested
Data collections
Gene metrics:23Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased startle reflex | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | heterozygote | Early adult | 1.89x10-8 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Atp1b1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| shortened QRS complex duration | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | heterozygote | Early adult | 2.01x10-5 | ||
| enlarged testis | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal testis morphology | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | heterozygote | Early adult | 9.63x10-7 | ||
| abnormal neural tube morphology | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal vitelline vasculature morphology | 1 supporting dataset | Atp1b1em1(IMPC)Mbp | homozygote | E9.5 | N/A * |
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Human diseases caused by Atp1b1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Atp1b1.
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| Atp1b1em1(IMPC)Mbp | Inter-exon deletion | | mouse |
| Atp1b1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Atp1b1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Atp1b1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |