Atp1a1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide

GeneMGI:88105Synonyms: Atpa-1

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Muscle Limbs/digits/tail Hematopoietic system Cardiovascular system Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	2 supporting datasets	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
thick ventricular wall	2 supporting datasets	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.41x10^-6
abnormal digit morphology	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.55x10^-7
decreased heart rate	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.05x10^-5
enlarged heart	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp1a1.

Associated images

15 images

X-ray

XRay Images Forepaw

30 images

X-ray

XRay Images Hind Leg and Hip

15 images

X-ray

XRay Images Skull Dorso Ventral Orientation

15 images

X-ray

XRay Images Skull Lateral Orientation

30 images

X-ray

XRay Images Whole Body Dorso Ventral

15 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Atp1a1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Atp1a1.

IMPC related publications

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External links

No external links available for Atp1a1.

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*Atp1a1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Atp1a1^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell

My Genes

Atp1a1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide

Physiological systems

10 Significantly impacted by the knock-out

12 No significant impact

2 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Atp1a1 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data