Atp1a1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Muscle Limbs/digits/tail Hematopoietic system Cardiovascular system Mortality/aging
12 No significant impact
2 Not tested
Data collections
Gene metrics:17Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
abnormal skin morphology | 2 supporting datasets | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
abnormal spleen morphology | 2 supporting datasets | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
abnormal thymus morphology | 1 supporting dataset | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
thick ventricular wall | 2 supporting datasets | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | 4.41x10-6 | ||
abnormal digit morphology | 1 supporting dataset | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | 4.55x10-7 | ||
decreased heart rate | 1 supporting dataset | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | 2.05x10-5 | ||
enlarged heart | 1 supporting dataset | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
abnormal uterus morphology | 1 supporting dataset | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
enlarged thymus | 1 supporting dataset | Atp1a1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Atp1a1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Atp1a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Atp1a1.
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Atp1a1em1(IMPC)Ccpcz | Exon Deletion | | mouse |
Atp1a1tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |