Apoe | apolipoprotein E

GeneMGI:88057Synonyms: Apoe

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Craniofacial

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

9Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal tooth morphology	1 supporting dataset	Apoe^tm1Unc	homozygote	Early adult	2.51x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Apoe^tm1Unc	homozygote	Early adult	6.31x10^-13
increased total body fat amount	1 supporting dataset	Apoe^tm1Unc	homozygote	Early adult	9.98x10^-5
increased circulating LDL cholesterol level	2 supporting datasets	Apoe^tm1Unc	homozygote	Early adult	6.18x10^-104
increased circulating cholesterol level	2 supporting datasets	Apoe^tm1Unc	homozygote	Early adult	5.49x10^-52
increased circulating triglyceride level	2 supporting datasets	Apoe^tm1Unc	homozygote	Early adult	2.29x10^-21
decreased circulating serum albumin level	1 supporting dataset	Apoe^tm1Unc	homozygote	Early adult	3.72x10^-5
abnormal glucose homeostasis	1 supporting dataset	Apoe^tm1Unc	homozygote	Early adult	6.84x10^-7
decreased circulating glucose level	1 supporting dataset	Apoe^tm1Unc	homozygote	Early adult	1.78x10^-8
increased circulating bilirubin level	1 supporting dataset	Apoe^tm1Unc	homozygote	Early adult	9.7x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Apoe.

Associated images

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Histopathology

There is no histopathology data found for Apoe.

IMPC related publications

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External links

No external links available for Apoe.

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*Apoe^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Apoe^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Apoe^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Apoe^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Apoe^{tm213835(pL1L2_GT1_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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