Ampd2 | adenosine monophosphate deaminase 2

GeneMGI:88016Synonyms: Ampd-2, 1200014F01Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased mean corpuscular hemoglobin concentration	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.13x10^-5
increased red blood cell distribution width	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.68x10^-7
decreased hematocrit	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.31x10^-5
increased mean platelet volume	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.22x10^-5
decreased circulating fructosamine level	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.79x10^-5
increased circulating cholesterol level	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	0
increased circulating amylase level	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.4x10^-12
thrombocytosis	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.72x10^-7
increased circulating potassium level	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.5x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Ampd2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ampd2.

Associated images

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Histopathology

There is no histopathology data found for Ampd2.

IMPC related publications

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External links

No external links available for Ampd2.

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*Ampd2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ampd2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ampd2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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