Ak4 | adenylate kinase 4

GeneMGI:87979Synonyms: D4Ertd274e, Ak3l1, +2 more

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Integument Endocrine/exocrine gland Digestive/alimentary Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased bone mineral content	2 supporting datasets	Ak4^{em1(IMPC)Kmpc}	homozygote	Early adult	3.98x10^-5
prolonged RR interval	1 supporting dataset	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	3.91x10^-8
abnormal coat/hair pigmentation	2 supporting datasets	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	1.33x10^-8
abnormal coat/ hair morphology	1 supporting dataset	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	1.57x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	N/A ^*
hyperactivity	2 supporting datasets	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	8.06x10^-6
increased circulating cholesterol level	1 supporting dataset	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	2.65x10^-8
abnormal duodenum morphology	1 supporting dataset	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	N/A ^*
decreased heart rate	1 supporting dataset	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	1.42x10^-7
abnormal ileum morphology	1 supporting dataset	Ak4^{em1(IMPC)Kmpc}	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ak4.

Associated images

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Histopathology

There is no histopathology data found for Ak4.

IMPC related publications

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External links

No external links available for Ak4.

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*Ak4^{em1(IMPC)Kmpc}*	Exon Deletion	‌	mouse
*Ak4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ak4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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