Agtr1a | angiotensin II receptor, type 1a

GeneMGI:87964Synonyms: Agt1ar, Agtr1a, +5 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Growth/size/body region Hematopoietic system Cardiovascular system Renal/urinary system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



enlarged spleen	1 supporting dataset	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
decreased erythrocyte cell number	1 supporting dataset	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	1.08x10^-8
increased red blood cell distribution width	1 supporting dataset	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	8.71x10^-6
decreased mean corpuscular hemoglobin	1 supporting dataset	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	2.4x10^-7
abnormal kidney morphology	2 supporting datasets	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Early adult	N/A ^*
polycystic kidney	2 supporting datasets	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
enlarged heart	2 supporting datasets	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
thrombocytosis	1 supporting dataset	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	5.5x10^-5
abnormal spleen morphology	1 supporting dataset	Agtr1a^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Agtr1a.

Associated images

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Histopathology

There is no histopathology data found for Agtr1a.

IMPC related publications

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External links

No external links available for Agtr1a.

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*Agtr1a^{em1(IMPC)Rbrc}*	Indel	‌	mouse
*Agtr1a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Agtr1a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Agtr1a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Agtr1a^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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