Adra2a | adrenergic receptor, alpha 2a
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Nervous system Behavior/neurological
16 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 1 supporting dataset | Adra2atm1.1(KOMP)Vlcg | homozygote | Early adult | 3.79x10-5 | ||
| small testis | 1 supporting dataset | Adra2atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| improved glucose tolerance | 2 supporting datasets | Adra2atm1.1(KOMP)Vlcg | homozygote | Early adult | 1.63x10-8 | ||
| hyperactivity | 4 supporting datasets | Adra2atm1.1(KOMP)Vlcg | homozygote | Early adult | 2.66x10-5 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Adra2atm1.1(KOMP)Vlcg | homozygote | Early adult | 7.5x10-9 | ||
| decreased startle reflex | 1 supporting dataset | Adra2atm1.1(KOMP)Vlcg | homozygote | Early adult | 2.5x10-5 | ||
| abnormal testis morphology | 1 supporting dataset | Adra2atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Adra2a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Adra2a.
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