Adk | adenosine kinase
Physiological systems
23 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Integument Growth/size/body region Respiratory system Hematopoietic system Behavior/neurological Skeleton Mortality/aging
14 No significant impact
1 Not tested
Data collections
Gene metrics:12Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged thymus | 1 supporting dataset | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased anxiety-related response | 1 supporting dataset | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | 5.36x10-5 | ||
| abnormal spleen morphology | 1 supporting dataset | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged lung | 1 supporting dataset | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased lung tissue damping | 2 supporting datasets | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | 2.58x10-5 | ||
| decreased locomotor activity | 2 supporting datasets | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | 3.03x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Adkem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | 4.78x10-11 | ||
| abnormal spine curvature | 1 supporting dataset | Adkem1(IMPC)Ccpcz | heterozygote | Early adult | 3.04x10-5 |
| | | | | | | | | | |
Human diseases caused by Adk mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Adk.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Adkem1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Adktm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Adktm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |