Aspa | aspartoacylase
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye Hematopoietic system Behavior/neurological
14 No significant impact
5 Not tested
Data collections
Gene metrics:16Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating alkaline phosphatase level | 1 supporting dataset | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.73x10-5 | ||
| decreased prepulse inhibition | 5 supporting datasets | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.53x10-15 | ||
| abnormal cornea morphology | 1 supporting dataset | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 2x10-8 | ||
| abnormal gait | 1 supporting dataset | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.06x10-6 | ||
| decreased grip strength | 2 supporting datasets | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.47x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.53x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.55x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.06x10-12 | ||
| hyperactivity | 2 supporting datasets | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.65x10-8 | ||
| decreased startle reflex | 1 supporting dataset | Aspatm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.1x10-6 |
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Human diseases caused by Aspa mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aspa.
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| Aspatm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Aspatm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Aspatm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Aspatm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Aspatm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Aspatm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |