Aspa | aspartoacylase

GeneMGI:87914Synonyms: nur7, aspartoacylase, +3 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Vision/eye Hematopoietic system Behavior/neurological

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.73x10^-5
decreased prepulse inhibition	5 supporting datasets	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.53x10^-15
abnormal cornea morphology	1 supporting dataset	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2x10^-8
abnormal gait	1 supporting dataset	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.06x10^-6
decreased grip strength	2 supporting datasets	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.47x10^-5
abnormal lens morphology	1 supporting dataset	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.53x10^-5
increased mean corpuscular volume	1 supporting dataset	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.55x10^-5
increased fasting circulating glucose level	1 supporting dataset	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.06x10^-12
hyperactivity	2 supporting datasets	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.65x10^-8
decreased startle reflex	1 supporting dataset	Aspa^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.1x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aspa.

Associated images

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Histopathology

There is no histopathology data found for Aspa.

IMPC related publications

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External links

No external links available for Aspa.

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*Aspa^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Aspa^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Aspa^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Aspa^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Aspa^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Aspa^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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