Acvr2b | activin receptor IIB

GeneMGI:87912Synonyms: ActRIIB

Physiological systems

22 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Growth/size/body region Mortality/aging Renal/urinary system

19 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Acvr2b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Acvr2b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Acvr2b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Acvr2b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
polycystic kidney	1 supporting dataset	Acvr2b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Acvr2b.

Associated images

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Histopathology

There is no histopathology data found for Acvr2b.

IMPC related publications

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External links

No external links available for Acvr2b.

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*Acvr2b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Acvr2b^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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