Actg1 | actin, gamma, cytoplasmic 1

GeneMGI:87906Synonyms: Actl, E51

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging Craniofacial Cardiovascular system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

6Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



spina bifida	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
microphthalmia	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
spina bifida	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
edema	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
pallor	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
hemorrhage	1 supporting dataset	Actg1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Actg1.

Associated images

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Histopathology

There is no histopathology data found for Actg1.

IMPC related publications

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External links

No external links available for Actg1.

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*Actg1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Actg1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Actg1^{tm213677(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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