Chrnb2 | cholinergic receptor nicotinic beta 2 subunit
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Vision/eye Cardiovascular system Mortality/aging
12 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| persistence of hyaloid vascular system | 1 supporting dataset | Chrnb2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.18x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Chrnb2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Chrnb2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased total body fat amount | 1 supporting dataset | Chrnb2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.01x10-5 | ||
| abnormal epididymis morphology | 1 supporting dataset | Chrnb2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Chrnb2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.78x10-5 |
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External links
No external links available for Chrnb2.
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| Chrnb2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Chrnb2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Chrnb2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |