Chrnb1 | cholinergic receptor nicotinic beta 1 subunit

GeneMGI:87890Synonyms: Acrb, AChR beta, +1 more

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Behavior/neurological Mortality/aging Craniofacial Cardiovascular system

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Chrnb1^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
hemorrhage	1 supporting dataset	Chrnb1^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Chrnb1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
cleft palate	1 supporting dataset	Chrnb1^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Chrnb1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Chrnb1^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
abnormal gait	1 supporting dataset	Chrnb1^em1(IMPC)Bay	heterozygote	Early adult	6.08x10^-6
abnormal facial morphology	2 supporting datasets	Chrnb1^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
abnormal locomotor behavior	1 supporting dataset	Chrnb1^em1(IMPC)Bay	heterozygote	Early adult	7.45x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chrnb1.

Associated images

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Histopathology

There is no histopathology data found for Chrnb1.

IMPC related publications

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External links

No external links available for Chrnb1.

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*Chrnb1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Chrnb1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Chrnb1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Chrnb1^{tm47456(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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