Ache | acetylcholinesterase
GeneMGI:87876
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
17 No significant impact
2 Not tested
Data collections
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| no spontaneous movement | 1 supporting dataset | Acheem1(IMPC)Mbp | heterozygote | E18.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Acheem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small heart | 1 supporting dataset | Acheem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Acheem1(IMPC)Mbp | homozygote | E18.5 | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Acheem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| increased neutrophil cell number | 1 supporting dataset | Acheem1(IMPC)Mbp | heterozygote | Early adult | 8.25x10-7 | ||
| hemorrhage | 1 supporting dataset | Acheem1(IMPC)Mbp | homozygote | E18.5 | N/A * |
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Human diseases caused by Ache mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ache.
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| Acheem1(IMPC)Mbp | Intra-exon deletion | | mouse |