Alkal2 | ALK and LTK ligand 2
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Integument Vision/eye Behavior/neurological Skeleton
13 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal skin morphology | 1 supporting dataset | Alkal2em1(IMPC)J | heterozygote | Early adult | 6.18x10-5 | ||
| exophthalmos | 1 supporting dataset | Alkal2em1(IMPC)J | homozygote | Early adult | 3.89x10-5 | ||
| cornea opacity | 1 supporting dataset | Alkal2em1(IMPC)J | homozygote | Early adult | 1.73x10-5 | ||
| narrow eye opening | 1 supporting dataset | Alkal2em1(IMPC)J | homozygote | Early adult | 1.16x10-5 | ||
| decreased grip strength | 2 supporting datasets | Alkal2em1(IMPC)J | heterozygote | Early adult | 2.43x10-6 | ||
| increased bone mineral content | 1 supporting dataset | Alkal2em1(IMPC)J | homozygote | Early adult | 4.53x10-5 |
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Human diseases caused by Alkal2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Alkal2.
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| Alkal2em1(IMPC)J | Exon Deletion | | mouse |
| Alkal2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Alkal2tm419188(Ifitm2_intron_L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |