Kcng2 | potassium voltage-gated channel, subfamily G, member 2
GeneMGI:3694646
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Muscle Behavior/neurological Cardiovascular system
13 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased cardiac muscle contractility | 2 supporting datasets | Kcng2em1(IMPC)Bay | homozygote | Early adult | 7.76x10-5 | ||
| hyperactivity | 1 supporting dataset | Kcng2em1(IMPC)Bay | homozygote | Early adult | 6.18x10-5 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Kcng2em1(IMPC)Bay | homozygote | Early adult | 4.74x10-9 | ||
| increased heart weight | 1 supporting dataset | Kcng2em1(IMPC)Bay | homozygote | Early adult | 4.3x10-5 | ||
| decreased cardiac stroke volume | 1 supporting dataset | Kcng2em1(IMPC)Bay | homozygote | Early adult | 2.44x10-6 |
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Human diseases caused by Kcng2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kcng2.
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| Kcng2em1(IMPC)Bay | Exon Deletion | | mouse |
| Kcng2tm466063(Ifitm2_intron_L1L2_GT2_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |