Trabd2b | TraB domain containing 2B

GeneMGI:3650152Synonyms: Gm12824, Hkat

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Hematopoietic system Skeleton Cardiovascular system Craniofacial

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal vertebral arch morphology	3 supporting datasets	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	2.09x10^-11
enlarged thymus	2 supporting datasets	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal vertebrae morphology	1 supporting dataset	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	7.17x10^-16
abnormal thymus morphology	2 supporting datasets	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
hydrocephaly	1 supporting dataset	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal head morphology	1 supporting dataset	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	7.32x10^-11
abnormal brain morphology	1 supporting dataset	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged adrenal glands	1 supporting dataset	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal snout morphology	1 supporting dataset	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	1.32x10^-11
abnormal cranium morphology	1 supporting dataset	Trabd2b^{em2(IMPC)Ccpcz}	homozygote	Early adult	3.81x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trabd2b.

Associated images

17 images

X-ray

XRay Images Forepaw

37 images

X-ray

XRay Images Hind Leg and Hip

17 images

X-ray

XRay Images Skull Dorso Ventral Orientation

17 images

X-ray

XRay Images Skull Lateral Orientation

36 images

X-ray

XRay Images Whole Body Dorso Ventral

18 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Trabd2b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Trabd2b.

IMPC related publications

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External links

No external links available for Trabd2b.

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*Trabd2b^{em2(IMPC)Ccpcz}*	Indel	‌	mouse
*Trabd2b^{tm99198(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes

Trabd2b | TraB domain containing 2B

Physiological systems

9 Significantly impacted by the knock-out

12 No significant impact

3 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Trabd2b mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data