Fam163a | family with sequence similarity 163, member A
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system
12 No significant impact
6 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased lean body mass | 1 supporting dataset | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 8.43x10-7 | ||
| increased erythrocyte cell number | 2 supporting datasets | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 6.53x10-9 | ||
| increased circulating total protein level | 1 supporting dataset | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 2.95x10-6 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 5.07x10-5 | ||
| increased hemoglobin content | 2 supporting datasets | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 2.68x10-8 | ||
| decreased total body fat amount | 1 supporting dataset | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 3.53x10-6 | ||
| increased leukocyte cell number | 1 supporting dataset | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 1.64x10-8 | ||
| increased hematocrit | 2 supporting datasets | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 1.73x10-8 | ||
| improved glucose tolerance | 1 supporting dataset | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 2.08x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Fam163atm2b(KOMP)Wtsi | homozygote | Early adult | 1.7x10-7 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Fam163a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fam163a.
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| Fam163atm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Fam163atm2b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |