Rapgefl1 | Rap guanine nucleotide exchange factor (GEF)-like 1

Physiological systems

11 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological

9 No significant impact

13 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating cholesterol level1 supporting datasetRapgefl1tm1a(KOMP)WtsihomozygoteEarly adult8.29x10-5 
increased thermal nociceptive threshold1 supporting datasetRapgefl1tm1a(KOMP)WtsihomozygoteEarly adult5.3x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rapgefl1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Rapgefl1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Rapgefl1tm43806(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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