Rft1 | RFT1 homolog
GeneMGI:3607791
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Limbs/digits/tail Hematopoietic system Skeleton Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| decreased lymphocyte cell number | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | heterozygote | Early adult | 9.52x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | heterozygote | Early adult | 7.39x10-11 | ||
| increased basophil cell number | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | heterozygote | Early adult | 2x10-5 | ||
| increased monocyte cell number | 2 supporting datasets | Rft1tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.31x10-6 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.17x10-5 | ||
| increased hemoglobin content | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.27x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.94x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Rft1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Rft1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rft1.
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| Rft1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rft1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rft1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Rft1tm43517(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |