Pcyox1l | prenylcysteine oxidase 1 like
GeneMGI:3606062
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Hearing/vestibular/ear Behavior/neurological Skeleton Cardiovascular system
11 No significant impact
7 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased heart weight | 1 supporting dataset | Pcyox1lem1(IMPC)J | homozygote | Early adult | 1.8x10-5 | ||
| abnormal sinus arrhythmia | 1 supporting dataset | Pcyox1lem1(IMPC)J | homozygote | Early adult | 3.92x10-6 | ||
| decreased startle reflex | 1 supporting dataset | Pcyox1lem1(IMPC)J | homozygote | Early adult | 3.47x10-7 | ||
| decreased grip strength | 4 supporting datasets | Pcyox1lem1(IMPC)J | homozygote | Early adult | 3x10-8 | ||
| increased heart rate variability | 1 supporting dataset | Pcyox1lem1(IMPC)J | homozygote | Early adult | 7.55x10-5 | ||
| hyperactivity | 7 supporting datasets | Pcyox1lem1(IMPC)J | homozygote | Early adult | 2.9x10-6 | ||
| decreased bone mineral content | 2 supporting datasets | Pcyox1lem1(IMPC)J | homozygote | Early adult | 1.3x10-7 | ||
| abnormal auditory brainstem response | 4 supporting datasets | Pcyox1lem1(IMPC)J | homozygote | Early adult | 1.67x10-8 | ||
| abnormal bone structure | 1 supporting dataset | Pcyox1lem1(IMPC)J | homozygote | Early adult | 4.56x10-11 | ||
| decreased lean body mass | 2 supporting datasets | Pcyox1lem1(IMPC)J | homozygote | Early adult | 7.34x10-9 |
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Human diseases caused by Pcyox1l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pcyox1l.
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| Pcyox1lem1(IMPC)J | Exon Deletion | | mouse |
| Pcyox1ltm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Pcyox1ltm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |