Piezo1 | piezo-type mechanosensitive ion channel component 1

GeneMGI:3603204Synonyms: Fam38a, Piezo1

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Limbs/digits/tail Behavior/neurological Mortality/aging Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased locomotor activity	4 supporting datasets	Piezo1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.24x10^-7
pale yolk sac	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.38x10^-29
embryonic growth retardation	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal placenta size	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
pallor	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	heterozygote	E12.5	N/A ^*
abnormal placenta size	1 supporting dataset	Piezo1^{tm1b(KOMP)Wtsi}	heterozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Piezo1.

Associated images

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Histopathology

There is no histopathology data found for Piezo1.

IMPC related publications

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External links

No external links available for Piezo1.

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*Piezo1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Piezo1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Piezo1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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