Piezo1 | piezo-type mechanosensitive ion channel component 1
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Limbs/digits/tail Behavior/neurological Mortality/aging Renal/urinary system
12 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 4 supporting datasets | Piezo1tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.24x10-7 | ||
| pale yolk sac | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | heterozygote | Early adult | 2.38x10-29 | ||
| embryonic growth retardation | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| pallor | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | heterozygote | E12.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Piezo1tm1b(KOMP)Wtsi | heterozygote | E12.5 | N/A * |
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Human diseases caused by Piezo1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Piezo1.
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| Piezo1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Piezo1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Piezo1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |