Firrm | FIGNL1 interacting regulator of recombination and mitosis

GeneMGI:3590554Synonyms: Flip, BC055324

Physiological systems

22 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Skeleton Mortality/aging

19 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Firrm^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased bone mineral density	1 supporting dataset	Firrm^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	4.77x10^-8
increased circulating cholesterol level	1 supporting dataset	Firrm^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.77x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Firrm^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	2.27x10^-5
abnormal pelvic girdle bone morphology	1 supporting dataset	Firrm^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.18x10^-8
abnormal bone mineralization	1 supporting dataset	Firrm^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.33x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Firrm^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.93x10^-5
increased bone mineral content	1 supporting dataset	Firrm^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	5.62x10^-8
decreased circulating glucose level	1 supporting dataset	Firrm^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.22x10^-5
increased circulating amylase level	1 supporting dataset	Firrm^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.71x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Firrm.

Associated images

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Histopathology

There is no histopathology data found for Firrm.

IMPC related publications

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External links

No external links available for Firrm.

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*Firrm^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Firrm^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Firrm^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Firrm^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Firrm^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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