Firrm | FIGNL1 interacting regulator of recombination and mitosis
Physiological systems
22 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Skeleton Mortality/aging
19 No significant impact
2 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Firrmtm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased bone mineral density | 1 supporting dataset | Firrmtm1a(EUCOMM)Hmgu | heterozygote | Early adult | 4.77x10-8 | ||
| increased circulating cholesterol level | 1 supporting dataset | Firrmtm1a(EUCOMM)Hmgu | heterozygote | Early adult | 1.77x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Firrmtm1a(EUCOMM)Hmgu | heterozygote | Early adult | 2.27x10-5 | ||
| abnormal pelvic girdle bone morphology | 1 supporting dataset | Firrmtm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.18x10-8 | ||
| abnormal bone mineralization | 1 supporting dataset | Firrmtm1a(EUCOMM)Hmgu | heterozygote | Early adult | 1.33x10-8 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Firrmtm1a(EUCOMM)Hmgu | heterozygote | Early adult | 1.93x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Firrmtm1a(EUCOMM)Hmgu | heterozygote | Early adult | 5.62x10-8 | ||
| decreased circulating glucose level | 1 supporting dataset | Firrmtm1a(EUCOMM)Hmgu | heterozygote | Early adult | 1.22x10-5 | ||
| increased circulating amylase level | 1 supporting dataset | Firrmtm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.71x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/1) | 1.67% (7/419) |
Human diseases caused by Firrm mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Firrm.
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| Firrmtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Firrmtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Firrmtm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Firrmtm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
| Firrmtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |