Elmod1 | ELMO/CED-12 domain containing 1

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Nervous system Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:47Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased total body fat amount	1 supporting dataset	Elmod1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.95x10^-7
abnormal startle reflex	1 supporting dataset	Elmod1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.98x10^-19
trunk curl	1 supporting dataset	Elmod1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.27x10^-16
increased lean body mass	1 supporting dataset	Elmod1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.94x10^-7
increased heart weight	1 supporting dataset	Elmod1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.99x10^-5
increased blood urea nitrogen level	1 supporting dataset	Elmod1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	9.54x10^-7
increased blood urea nitrogen level	1 supporting dataset	Elmod1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.71x10^-6
abnormal auditory brainstem response	5 supporting datasets	Elmod1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.15x10^-7
decreased grip strength	1 supporting dataset	Elmod1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.4x10^-5
increased startle reflex	8 supporting datasets	Elmod1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	8.19x10^-41

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Elmod1.

Associated images

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Histopathology

There is no histopathology data found for Elmod1.

IMPC related publications

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External links

No external links available for Elmod1.

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*Elmod1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Elmod1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Elmod1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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