Elmod1 | ELMO/CED-12 domain containing 1
GeneMGI:3583900
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Nervous system Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
11 No significant impact
2 Not tested
Data collections
Gene metrics:47Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased total body fat amount | 1 supporting dataset | Elmod1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.95x10-7 | ||
| abnormal startle reflex | 1 supporting dataset | Elmod1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.98x10-19 | ||
| trunk curl | 1 supporting dataset | Elmod1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.27x10-16 | ||
| increased lean body mass | 1 supporting dataset | Elmod1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.94x10-7 | ||
| increased heart weight | 1 supporting dataset | Elmod1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.99x10-5 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Elmod1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 9.54x10-7 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Elmod1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.71x10-6 | ||
| abnormal auditory brainstem response | 5 supporting datasets | Elmod1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.15x10-7 | ||
| decreased grip strength | 1 supporting dataset | Elmod1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.4x10-5 | ||
| increased startle reflex | 8 supporting datasets | Elmod1tm1a(EUCOMM)Hmgu | homozygote | Early adult | 8.19x10-41 |
| ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Elmod1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Elmod1.
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| Elmod1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | ‌ | targeting vector ES Cell mouse |
| Elmod1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | ‌ | mouse |
| Elmod1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ‌ | ES Cell |