Dgkk | diacylglycerol kinase kappa

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating cholesterol level1 supporting datasetDgkkem1(IMPC)IcshemizygoteEarly adult5.02x10-6 
increased startle reflex1 supporting datasetDgkkem1(IMPC)IcshemizygoteEarly adult2.16x10-9 
increased circulating alkaline phosphatase level1 supporting datasetDgkkem1(IMPC)IcshemizygoteEarly adult3.45x10-5 
abnormal locomotor behavior1 supporting datasetDgkkem1(IMPC)IcshemizygoteEarly adult7.45x10-5 
decreased grip strength1 supporting datasetDgkkem1(IMPC)IcshemizygoteEarly adult4.2x10-6 
increased circulating HDL cholesterol level1 supporting datasetDgkkem1(IMPC)IcshemizygoteEarly adult7.76x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dgkkem1(IMPC)IcsDeletionmouse
Dgkktm106254(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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