Otulin | OTU deubiquitinase with linear linkage specificity

GeneMGI:3577015Synonyms: gumby, Fam105b, +2 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Immune system Hematopoietic system Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal spleen morphology	2 supporting datasets	Otulin^em1(IMPC)Bay	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Otulin^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Otulin^em1(IMPC)Bay	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Otulin.

Associated images

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Histopathology

There is no histopathology data found for Otulin.

IMPC related publications

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External links

No external links available for Otulin.

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*Otulin^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Otulin^em1H*	Point Mutation	‌	mouse
*Otulin^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Otulin^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Otulin^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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