Mdc1 | mediator of DNA damage checkpoint 1
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Reproductive system Behavior/neurological Cardiovascular system
14 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased cardiac stroke volume | 1 supporting dataset | Mdc1em1(IMPC)Bay | homozygote | Late adult | 4.82x10-6 | ||
| decreased cardiac output | 1 supporting dataset | Mdc1em1(IMPC)Bay | homozygote | Late adult | 1.59x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Mdc1em1(IMPC)Bay | homozygote | Late adult | 6.88x10-5 | ||
| male infertility | 1 supporting dataset | Mdc1em1(IMPC)Bay | homozygote | Early adult | N/A * |
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Human diseases caused by Mdc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mdc1.
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| Mdc1em1(IMPC)Bay | Exon Deletion | | mouse |
| Mdc1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Mdc1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |