Neurl2 | neuralized E3 ubiquitin protein ligase 2

GeneMGI:3043305Synonyms: Ozz, Ozz-E3

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Cardiovascular system

12 No significant impact

6 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

decreased leukocyte cell number1 supporting datasetNeurl2tm1.1(KOMP)VlcghomozygoteEarly adult4.27x10-7 
decreased circulating iron level1 supporting datasetNeurl2tm1.1(KOMP)VlcghomozygoteEarly adult6.5x10-9 
increased heart weight1 supporting datasetNeurl2tm1.1(KOMP)VlcghomozygoteEarly adult9.3x10-6 
abnormal coat appearance1 supporting datasetNeurl2tm1.1(KOMP)VlcghomozygoteEarly adult3.94x10-5 
decreased circulating glucose level1 supporting datasetNeurl2tm1.1(KOMP)VlcghomozygoteEarly adult3.25x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Neurl2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Neurl2tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Neurl2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Neurl2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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