Slc17a8 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Digestive/alimentary Nervous system Vision/eye Hearing/vestibular/ear Behavior/neurological Renal/urinary system
12 No significant impact
3 Not tested
Data collections
Gene metrics:14Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal auditory brainstem response | 6 supporting datasets | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | 1.83x10-6 | ||
| abnormal eye morphology | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased prepulse inhibition | 7 supporting datasets | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | 4.44x10-57 | ||
| abnormal adrenal gland morphology | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| cataract | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | 1.88x10-5 | ||
| abnormal lymph node morphology | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal colon morphology | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased startle reflex | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | 1.13x10-13 | ||
| abnormal startle reflex | 1 supporting dataset | Slc17a8em1(IMPC)Mbp | homozygote | Early adult | 1.15x10-18 |
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Human diseases caused by Slc17a8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Slc17a8.
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| Slc17a8em1(IMPC)Mbp | Exon Deletion | | mouse |
| Slc17a8tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Slc17a8tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Slc17a8tm42931(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |