Rsad1 | radical S-adenosyl methionine domain containing 1
GeneMGI:3039628
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Mortality/aging
13 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:41Adult tissues
0Embryo tissues
| decreased blood urea nitrogen level | 1 supporting dataset | Rsad1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 6.48x10-7 | ||
| small thymus | 1 supporting dataset | Rsad1tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| small adrenal glands | 1 supporting dataset | Rsad1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Rsad1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Rsad1tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Rsad1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| enlarged lymph nodes | 2 supporting datasets | Rsad1tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | Section images | 50% (1/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 50% (1/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 50% (1/2) | 1.67% (7/419) |
| eye | heterozygote | n/a | 0% (0/2) | 0% (0/335) |
| heart | heterozygote | n/a | 0% (0/2) | 0.36% (2/550) |
Human diseases caused by Rsad1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rsad1.
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| Rsad1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Rsad1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Rsad1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rsad1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Rsad1tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rsad1tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rsad1tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |