Fbxl19 | F-box and leucine-rich repeat protein 19

GeneMGI:3039600Synonyms: Fbl19

Physiological systems

16 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system

13 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased basophil cell number	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.58x10^-7
increased mean platelet volume	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.43x10^-6
increased neutrophil cell number	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.81x10^-6
increased monocyte cell number	2 supporting datasets	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.33x10^-57
increased leukocyte cell number	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.32x10^-5
decreased lymphocyte cell number	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.45x10^-10
increased eosinophil cell number	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.76x10^-6
decreased circulating glucose level	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.65x10^-6
decreased circulating total protein level	1 supporting dataset	Fbxl19^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.49x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxl19.

Associated images

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Histopathology

There is no histopathology data found for Fbxl19.

IMPC related publications

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External links

No external links available for Fbxl19.

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*Fbxl19^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fbxl19^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fbxl19^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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