Duox2 | dual oxidase 2
Physiological systems
19 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
9 No significant impact
5 Not tested
Data collections
Gene metrics:29Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| small heart | 2 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased grip strength | 3 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | 1.84x10-35 | ||
| decreased prepulse inhibition | 6 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | 2.53x10-48 | ||
| small spleen | 2 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased circulating cholesterol level | 1 supporting dataset | Duox2em1(IMPC)Mbp | homozygote | Early adult | 2.37x10-21 | ||
| small liver | 2 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased freezing behavior | 2 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | 3.4x10-29 | ||
| abnormal heart morphology | 2 supporting datasets | Duox2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased circulating creatinine level | 1 supporting dataset | Duox2em1(IMPC)Mbp | homozygote | Early adult | 2.54x10-7 |
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Human diseases caused by Duox2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Duox2.
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| Duox2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Duox2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Duox2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Duox2tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Duox2tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Duox2tm44076(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |