Duox2 | dual oxidase 2

GeneMGI:3036280Synonyms: A430065P05Rik

Physiological systems

19 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

9 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:29Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small heart	2 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased grip strength	3 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	1.84x10^-35
decreased prepulse inhibition	6 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	2.53x10^-48
small spleen	2 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Duox2^em1(IMPC)Mbp	homozygote	Early adult	2.37x10^-21
small liver	2 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased freezing behavior	2 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	3.4x10^-29
abnormal heart morphology	2 supporting datasets	Duox2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased circulating creatinine level	1 supporting dataset	Duox2^em1(IMPC)Mbp	homozygote	Early adult	2.54x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Duox2.

Associated images

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Histopathology

There is no histopathology data found for Duox2.

IMPC related publications

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External links

No external links available for Duox2.

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*Duox2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Duox2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Duox2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Duox2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Duox2^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Duox2^{tm44076(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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