Lmtk2 | lemur tyrosine kinase 2
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Cardiovascular system Renal/urinary system
15 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal testis morphology | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| male infertility | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small testis | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | 1.82x10-14 | ||
| decreased heart rate | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | 6.89x10-5 | ||
| small kidney | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| prolonged RR interval | 1 supporting dataset | Lmtk2em1(IMPC)Mbp | homozygote | Early adult | 9.19x10-7 |
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Human diseases caused by Lmtk2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Lmtk2.
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| Lmtk2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Lmtk2tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Lmtk2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Lmtk2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |