Cldn19 | claudin 19
GeneMGI:3033992
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Behavior/neurological Cardiovascular system
14 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
51Embryo tissues
| abnormal sleep behavior | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.9x10-6 | ||
| shortened ST segment | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.54x10-5 | ||
| shortened PR interval | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.81x10-6 | ||
| increased circulating sodium level | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.86x10-6 | ||
| increased heart weight | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.13x10-6 | ||
| decreased circulating free fatty acids level | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.6x10-7 | ||
| shortened PQ interval | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.21x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/1) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
Human diseases caused by Cldn19 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cldn19.
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| Cldn19tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Cldn19tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Cldn19tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cldn19tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |