Cldn19 | claudin 19

GeneMGI:3033992

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Behavior/neurological Cardiovascular system

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:49Adult tissues

51Embryo tissues

Phenotypes

Phy. System:



abnormal sleep behavior	1 supporting dataset	Cldn19^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.9x10^-6
shortened ST segment	1 supporting dataset	Cldn19^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.54x10^-5
shortened PR interval	1 supporting dataset	Cldn19^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.81x10^-6
increased circulating sodium level	1 supporting dataset	Cldn19^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.86x10^-6
increased heart weight	1 supporting dataset	Cldn19^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.13x10^-6
decreased circulating free fatty acids level	1 supporting dataset	Cldn19^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.6x10^-7
shortened PQ interval	1 supporting dataset	Cldn19^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.21x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cldn19.

Associated images

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Histopathology

There is no histopathology data found for Cldn19.

IMPC related publications

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External links

No external links available for Cldn19.

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*Cldn19^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Cldn19^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Cldn19^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cldn19^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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