Kcnf1 | potassium voltage-gated channel, subfamily F, member 1
Physiological systems
19 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Behavior/neurological
18 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased thigmotaxis | 2 supporting datasets | Kcnf1em1(IMPC)H | homozygote | Early adult | 9.61x10-8 | ||
| decreased anxiety-related response | 1 supporting dataset | Kcnf1em1(IMPC)H | homozygote | Late adult | 2.64x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Kcnf1em1(IMPC)H | homozygote | Late adult | 3.95x10-5 | ||
| hyperactivity | 4 supporting datasets | Kcnf1em1(IMPC)H | homozygote | Early adult | 1.06x10-9 | ||
| hyperactivity | 4 supporting datasets | Kcnf1em1(IMPC)H | homozygote | Late adult | 3.39x10-6 | ||
| abnormal behavior | 1 supporting dataset | Kcnf1em1(IMPC)H | homozygote | Early adult | 9.61x10-8 | ||
| decreased locomotor activity | 1 supporting dataset | Kcnf1em1(IMPC)H | homozygote | Early adult | 5.22x10-5 | ||
| abnormal behavior | 1 supporting dataset | Kcnf1em1(IMPC)H | homozygote | Late adult | 4.74x10-5 | ||
| decreased anxiety-related response | 1 supporting dataset | Kcnf1em1(IMPC)H | homozygote | Early adult | 3x10-9 |
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Human diseases caused by Kcnf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kcnf1.
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| Kcnf1em1(IMPC)H | Intra-exon deletion | | mouse |