Klhl6 | kelch-like 6
GeneMGI:2686922
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system Cardiovascular system Renal/urinary system
14 No significant impact
2 Not tested
Data collections
Gene metrics:22Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased T-helper cell number | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | 2.96x10-5 | ||
| small testis | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased effector memory T-helper cell number | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | 1.51x10-5 | ||
| increased CD4-positive, alpha-beta T cell number | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | 1.76x10-5 | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased CD8-positive, naive alpha-beta T cell number | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | 3.8x10-5 | ||
| abnormal spleen morphology | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Klhl6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Klhl6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Klhl6.
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| Klhl6em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Klhl6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Klhl6tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |