Klhl6 | kelch-like 6

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system Cardiovascular system Renal/urinary system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased T-helper cell number	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.96x10^-5
small testis	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased effector memory T-helper cell number	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.51x10^-5
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.76x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased CD8-positive, naive alpha-beta T cell number	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.8x10^-5
abnormal spleen morphology	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Klhl6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Klhl6.

Associated images

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Histopathology

There is no histopathology data found for Klhl6.

IMPC related publications

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External links

No external links available for Klhl6.

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*Klhl6^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Klhl6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Klhl6^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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