Pdp1 | pyruvate dehydrogenase phosphatase catalytic subunit 1

GeneMGI:2685870Synonyms: LOC381511, Ppm2c

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small testis	1 supporting dataset	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased heart weight	2 supporting datasets	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	1.87x10^-6
increased mean corpuscular volume	1 supporting dataset	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	3.96x10^-5
female infertility	1 supporting dataset	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	6.23x10^-5
abnormal testis morphology	1 supporting dataset	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	1.9x10^-6
decreased grip strength	1 supporting dataset	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	4.63x10^-6
improved glucose tolerance	2 supporting datasets	Pdp1^em1(IMPC)Mbp	homozygote	Early adult	1.2x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Pdp1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Pdp1.

IMPC related publications

Loading...

External links

No external links available for Pdp1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Pdp1^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Pdp1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pdp1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes