Prss48 | serine protease 48

GeneMGI:2685865Synonyms: Gm1019, Esspl

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Renal/urinary system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal seminal vesicle morphology	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
small seminal vesicle	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal vertebral arch morphology	2 supporting datasets	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.85x10^-6
abnormal digit morphology	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.99x10^-8
abnormal kidney morphology	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased respiratory quotient	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.91x10^-7
decreased lean body mass	1 supporting dataset	Prss48^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.21x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prss48.

Associated images

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Histopathology

There is no histopathology data found for Prss48.

IMPC related publications

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External links

No external links available for Prss48.

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*Prss48^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Prss48^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Prss48^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Prss48^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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