Thsd7a | thrombospondin, type I, domain containing 7A
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Growth/size/body region Vision/eye Behavior/neurological Skeleton
14 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Thsd7atm1b(KOMP)Mbp | homozygote | Late adult | 8.5x10-7 | ||
| hyperactivity | 7 supporting datasets | Thsd7atm1b(KOMP)Mbp | homozygote | Late adult | 1.01x10-14 | ||
| cataract | 1 supporting dataset | Thsd7atm1b(KOMP)Mbp | homozygote | Late adult | 3.53x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Thsd7atm1b(KOMP)Mbp | homozygote | Early adult | 1.45x10-6 | ||
| decreased bone mineral content | 1 supporting dataset | Thsd7atm1b(KOMP)Mbp | homozygote | Early adult | 5.97x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Thsd7atm1b(KOMP)Mbp | homozygote | Late adult | 1.2x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Thsd7a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Thsd7a.
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| Thsd7atm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Thsd7atm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Thsd7atm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |