Pou2af3 | POU class 2 homeobox associating factor 3

GeneMGI:2685530Synonyms: OCA-T2, Gm684, +2 more

Physiological systems

17 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased heart rate variability	1 supporting dataset	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	3.34x10^-5
decreased bone mineral content	2 supporting datasets	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	2.63x10^-8
decreased prepulse inhibition	5 supporting datasets	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	5.54x10^-11
increased neutrophil cell number	2 supporting datasets	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.96x10^-6
decreased lymphocyte cell number	1 supporting dataset	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.44x10^-5
short tibia	1 supporting dataset	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.19x10^-6
increased blood urea nitrogen level	1 supporting dataset	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.85x10^-6
decreased startle reflex	1 supporting dataset	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	2.29x10^-6
decreased bone mineral density	1 supporting dataset	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.68x10^-13
increased grip strength	2 supporting datasets	Pou2af3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	6x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pou2af3.

Associated images

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Histopathology

There is no histopathology data found for Pou2af3.

IMPC related publications

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External links

No external links available for Pou2af3.

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*Pou2af3^{tm1a(NCOM)Mfgc}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pou2af3^{tm1b(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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