Atp13a3 | ATPase type 13A3
Physiological systems
17 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
7 No significant impact
7 Not tested
Data collections
Gene metrics:29Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina blood vessel morphology | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 1.01x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 1.74x10-106 | ||
| decreased locomotor activity | 4 supporting datasets | Atp13a3em1(IMPC)J | homozygote | Early adult | 1.57x10-11 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 4.3x10-9 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 2.27x10-5 | ||
| increased hematocrit | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 3.89x10-46 | ||
| decreased circulating glucose level | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 2.31x10-16 | ||
| improved glucose tolerance | 2 supporting datasets | Atp13a3em1(IMPC)J | homozygote | Early adult | 2x10-20 | ||
| increased erythrocyte cell number | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 2.15x10-35 | ||
| decreased circulating total protein level | 1 supporting dataset | Atp13a3em1(IMPC)J | homozygote | Early adult | 8.17x10-35 |
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Human diseases caused by Atp13a3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Atp13a3.
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| Atp13a3em1(IMPC)J | Exon Deletion | | mouse |
| Atp13a3em2H | Point Mutation | | mouse |
| Atp13a3tm46896(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |