Ptchd1 | patched domain containing 1

GeneMGI:2685233Synonyms: 9630036J22Rik

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased erythrocyte cell number	1 supporting dataset	Ptchd1^{tm1b(KOMP)IcsOrl}	homozygote	Early adult	5.03x10^-5
hyperactivity	9 supporting datasets	Ptchd1^{tm1b(KOMP)IcsOrl}	homozygote	Early adult	1.58x10^-12
hyperactivity	7 supporting datasets	Ptchd1^{tm1b(KOMP)IcsOrl}	hemizygote	Early adult	2.76x10^-13
increased exploration in new environment	1 supporting dataset	Ptchd1^{tm1b(KOMP)IcsOrl}	hemizygote	Early adult	5.15x10^-7
increased vertical activity	1 supporting dataset	Ptchd1^{tm1b(KOMP)IcsOrl}	hemizygote	Early adult	2.27x10^-13
increased lean body mass	1 supporting dataset	Ptchd1^{tm1b(KOMP)IcsOrl}	hemizygote	Early adult	9.78x10^-5
abnormal cued conditioning behavior	1 supporting dataset	Ptchd1^{tm1b(KOMP)IcsOrl}	homozygote	Early adult	3.33x10^-5
abnormal auditory brainstem response	2 supporting datasets	Ptchd1^{tm1b(KOMP)IcsOrl}	hemizygote	Early adult	7.59x10^-9
increased aggression	1 supporting dataset	Ptchd1^{tm1b(KOMP)IcsOrl}	hemizygote	Early adult	3.38x10^-6
increased circulating creatinine level	1 supporting dataset	Ptchd1^{tm1b(KOMP)IcsOrl}	homozygote	Early adult	5.02x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ptchd1.

Associated images

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Histopathology

There is no histopathology data found for Ptchd1.

IMPC related publications

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External links

No external links available for Ptchd1.

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*Ptchd1^{tm1a(KOMP)IcsOrl}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	mouse
*Ptchd1^{tm1b(KOMP)IcsOrl}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ptchd1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ptchd1^{tm94175(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ptchd1^{tm94175(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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