Man1b1 | mannosidase, alpha, class 1B, member 1

GeneMGI:2684954Synonyms: LOC227619, MANA-ER, +1 more

Physiological systems

15 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Cardiovascular system Mortality/aging

13 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:2Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased heart left ventricle size1 supporting datasetMan1b1em1(IMPC)BayheterozygoteEarly adult1.48x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetMan1b1em1(IMPC)BayhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Order Mouse and ES Cells

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Man1b1em1(IMPC)BayExon Deletionmouse
Man1b1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Man1b1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Man1b1tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Man1b1tm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Man1b1tm33640(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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