Cenpj | centromere protein J
Physiological systems
19 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Limbs/digits/tail Behavior/neurological Skeleton Craniofacial
11 No significant impact
5 Not tested
Data collections
Gene metrics:20Significant phenotypes
4Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal tail movements | 1 supporting dataset | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.58x10-9 | ||
| abnormal behavior | 10 supporting datasets | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.41x10-16 | ||
| increased total body fat amount | 1 supporting dataset | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.36x10-5 | ||
| decreased body weight | 5 supporting datasets | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.06x10-24 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.4x10-8 | ||
| abnormal joint morphology | 1 supporting dataset | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.64x10-14 | ||
| abnormal external female genitalia morphology | 2 supporting datasets | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.66x10-15 | ||
| abnormal cranium morphology | 1 supporting dataset | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.46x10-11 | ||
| abnormal ulna morphology | 1 supporting dataset | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.81x10-9 | ||
| abnormal head morphology | 1 supporting dataset | Cenpjtm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.18x10-14 |
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| adrenal gland | heterozygote | n/a | 0% (0/3) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/3) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (3/3) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/3) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/3) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Cenpj mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cenpj.
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| Cenpjtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cenpjtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |