Dcaf15 | DDB1 and CUL4 associated factor 15

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Craniofacial Cardiovascular system Renal/urinary system Homeostasis/metabolism Pigmentation Vision/eye Respiratory system Skeleton

7 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:33Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

27Embryo tissues

Phenotypes

Phy. System:



increased airway resistance	2 supporting datasets	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.2x10^-6
enlarged uterus	1 supporting dataset	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal vertebral arch morphology	2 supporting datasets	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	8.55x10^-7
enlarged thymus	1 supporting dataset	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal coat/hair pigmentation	4 supporting datasets	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.6x10^-5
small heart	1 supporting dataset	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased CD4-positive, alpha-beta T cell number	1 supporting dataset	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.23x10^-16
abnormal uterus morphology	1 supporting dataset	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal rib morphology	1 supporting dataset	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.16x10^-6
single kidney	1 supporting dataset	Dcaf15^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dcaf15.

Associated images

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Histopathology

There is no histopathology data found for Dcaf15.

IMPC related publications

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External links

No external links available for Dcaf15.

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*Dcaf15^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dcaf15^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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