Dcaf15 | DDB1 and CUL4 associated factor 15
GeneMGI:2684420
Physiological systems
21 / 24 physiological systems tested
14 Significantly impacted by the knock-out
Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Craniofacial Cardiovascular system Renal/urinary system Homeostasis/metabolism Pigmentation Vision/eye Respiratory system Skeleton
7 No significant impact
3 Not tested
Data collections
Gene metrics:33Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
27Embryo tissues
| increased airway resistance | 2 supporting datasets | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | 4.2x10-6 | ||
| enlarged uterus | 1 supporting dataset | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal vertebral arch morphology | 2 supporting datasets | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | 8.55x10-7 | ||
| enlarged thymus | 1 supporting dataset | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal coat/hair pigmentation | 4 supporting datasets | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.6x10-5 | ||
| small heart | 1 supporting dataset | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased CD4-positive, alpha-beta T cell number | 1 supporting dataset | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | 2.23x10-16 | ||
| abnormal uterus morphology | 1 supporting dataset | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal rib morphology | 1 supporting dataset | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.16x10-6 | ||
| single kidney | 1 supporting dataset | Dcaf15tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | Section images | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | n/a | 0% (0/17) |
| bone | heterozygote | Section images | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
Human diseases caused by Dcaf15 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dcaf15.
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| Dcaf15tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dcaf15tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |