Togaram1 | TOG array regulator of axonemal microtubules 1
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Cardiovascular system Mortality/aging Craniofacial
12 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| anophthalmia | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E15.5 | N/A * | ||
| abnormal forebrain morphology | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E12.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E12.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E15.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E12.5 | N/A * | ||
| abnormal limb bud morphology | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E12.5 | N/A * | ||
| polydactyly | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E15.5 | N/A * | ||
| facial cleft | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E12.5 | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Togaram1em1(IMPC)J | homozygote | E15.5 | N/A * |
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Human diseases caused by Togaram1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Togaram1.
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| Togaram1em1(IMPC)J | Exon Deletion | | mouse |
| Togaram1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Togaram1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |