Kmt2d | lysine (K)-specific methyltransferase 2D

GeneMGI:2682319Synonyms: bapa, C430014K11Rik, +2 more

Physiological systems

15 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system

11 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	2.52x10^-8
decreased body length	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	1.03x10^-6
decreased circulating chloride level	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	1.13x10^-8
increased circulating amylase level	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	5.11x10^-10
decreased leukocyte cell number	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	5.25x10^-5
decreased erythrocyte cell number	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	7.07x10^-7
decreased circulating sodium level	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	2.58x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Kmt2d^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	3.82x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kmt2d.

Associated images

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Histopathology

There is no histopathology data found for Kmt2d.

IMPC related publications

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External links

No external links available for Kmt2d.

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*Kmt2d^{tm1(IMPC)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Kmt2d^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Kmt2d^{tm1.2(IMPC)Wtsi}*	Reporter-tagged deletion allele (post Flp, with no reporter and selection cassette)	‌	mouse
*Kmt2d^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Kmt2d^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Kmt2d^{tm403150(pL1L2_frt_BetactP_neo_frt_lox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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