Chsy1 | chondroitin sulfate synthase 1

GeneMGI:2681120Synonyms: skt

Physiological systems

20 / 24 physiological systems tested

12 Significantly impacted by the knock-out

 Immune system Integument Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Vision/eye Liver/biliary system Nervous system Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

8 No significant impact

4 Not tested

Gene metrics:28Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal cecum morphology1 supporting datasetChsy1em1(IMPC)MbphomozygoteEarly adultN/A * 
hydrocephaly2 supporting datasetsChsy1em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal skin morphology1 supporting datasetChsy1em1(IMPC)MbphomozygoteEarly adultN/A * 
decreased bone mineral density1 supporting datasetChsy1em1(IMPC)MbphomozygoteEarly adult2.43x10-5 
decreased bone mineral content2 supporting datasetsChsy1em1(IMPC)MbphomozygoteEarly adult2.49x10-14 
abnormal retina morphology1 supporting datasetChsy1em1(IMPC)MbphomozygoteEarly adult3.05x10-5 
microphthalmia2 supporting datasetsChsy1em1(IMPC)MbphomozygoteEarly adultN/A * 
cornea opacity1 supporting datasetChsy1em1(IMPC)MbphomozygoteEarly adult2.55x10-10 
abnormal eye morphology2 supporting datasetsChsy1em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal spleen morphology1 supporting datasetChsy1em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Chsy1em1(IMPC)MbpExon Deletionmouse

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