Dcun1d3 | defective in cullin neddylation 1 domain containing 3

GeneMGI:2679003Synonyms: DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae), 1700020A13Rik

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating cholesterol level	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	2.15x10^-9
increased circulating bilirubin level	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	1.33x10^-18
decreased total body fat amount	2 supporting datasets	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	6.45x10^-5
increased red blood cell distribution width	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	1.48x10^-6
increased lean body mass	2 supporting datasets	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	2.23x10^-5
improved glucose tolerance	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	1.02x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
decreased fasting circulating glucose level	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	8.75x10^-11
decreased circulating glucose level	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	2.26x10^-8
thrombocytopenia	1 supporting dataset	Dcun1d3^{em1(IMPC)Wtsi}	homozygote	Early adult	6.1x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dcun1d3.

Associated images

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Histopathology

There is no histopathology data found for Dcun1d3.

IMPC related publications

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External links

No external links available for Dcun1d3.

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*Dcun1d3^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Dcun1d3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dcun1d3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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