Slc24a5 | solute carrier family 24, member 5
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Vision/eye Behavior/neurological
12 No significant impact
7 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| abnormal coat/hair pigmentation | 7 supporting datasets | Slc24a5tm1b(KOMP)Mbp | homozygote | Early adult | 4.27x10-8 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Slc24a5tm1b(KOMP)Mbp | homozygote | Early adult | 1.76x10-9 | ||
| impaired righting response | 1 supporting dataset | Slc24a5tm1b(KOMP)Mbp | homozygote | Early adult | 2.14x10-7 | ||
| abnormal iris transillumination | 1 supporting dataset | Slc24a5tm1b(KOMP)Mbp | homozygote | Early adult | 1.97x10-16 | ||
| increased grip strength | 2 supporting datasets | Slc24a5tm1b(KOMP)Mbp | homozygote | Early adult | 4.03x10-5 | ||
| increased circulating sodium level | 1 supporting dataset | Slc24a5tm1b(KOMP)Mbp | homozygote | Early adult | 3.52x10-8 | ||
| abnormal retina morphology | 1 supporting dataset | Slc24a5tm1b(KOMP)Mbp | homozygote | Early adult | 4.19x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Slc24a5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc24a5.
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| Slc24a5tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc24a5tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Slc24a5tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Slc24a5tm43958(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |